Fantasy Football Week 4: Key Picks and Projections

ESPN Fantasy, October 5, 2025 — As Week 4 of the NFL season approaches, fantasy players are gearing up with their lineups. This week’s analysis includes player projections, matchups, and useful advice for both seasoned players and newcomers.

The projected score for the Steelers–Vikings matchup is a tie at 19. The Steelers enter with a 51% win probability. Running back Ty Chandler of the Vikings enjoyed significant playing time recently, but his limited targets could impact his fantasy potential.

Meanwhile, the Commanders are set to face the Falcons, projected to score 24-20. Commanders’ running back, who stepped into a bigger role following a teammate’s injury, is expected to be a crucial fantasy option. Washington’s Terry McLaurin is anticipated to be covered closely by Falcons cornerback A.J. Terrell, making for an intriguing matchup.

In the Bills–Saints game, the Bills hold a commanding 93% win probability with a projected score of 32-17. Rookie tight end Dalton Kincaid is seeing increased action, and while his production has been steady, he may still be regarded as a low-end TE1.

The Lions are predicted to triumph over the Browns by a score of 28-17, with an 85% win probability. The potential for two fantasy-relevant tight ends on the Browns raises questions about which player will emerge as the top option.

In an even matchup, the Patriots and Panthers are projected to tie at 21. Patriots tight end Hunter Henry recently had standout performances, demonstrating his potential as a viable starter in upcoming weeks.

The Chargers are projected to win against the Giants 26-18, with a 78% probability. Rookies could play a key role here, especially with injuries affecting established players. The Chargers’ defense is also one to watch, having performed well so far this season.

Players such as Christian Watson and Cam Akers are also being monitored closely; their performances could sway fantasy outcomes considerably this week. Games like Texans–Titans and Packers–Cowboys will also keep fans on the edge of their seats, with various players on both sides likely impacting their team’s success in fantasy leagues.

As always, make sure to check injury reports and player updates before finalizing any lineup. Adjustments in projections may arise leading up to kickoff, allowing for last-minute strategic opportunities.