College Football’s Week 10: Key Matchups and Playoff Implications

Columbus, Ohio — As the 2025 college football season progresses, Week 10 promises to be pivotal with multiple ranked teams facing off on the road this Saturday. The slate includes crucial matchups featuring teams vying for positions in the College Football Playoff (CFP).

Highlighted games include No. 1 Ohio State against No. 2 Indiana, and No. 8 Vanderbilt visiting No. 20 Texas. According to SP+, there is only a 9% chance that all ranked teams in action will win, suggesting that upsets are likely to alter the playoff landscape.

The first ranks of teams, including Indiana, Ohio State, and Texas A&M, appear to be in solid positions with playoff odds well over 90%. However, road games present unpredictable challenges. For instance, Indiana has a strong standing, favored by 21.5 points against Maryland, who struggles after September.

“If Indiana brings even their B-game, they’ll cruise,” noted analysts discussing the matchup against a faltering Maryland team that has lost four of its last five games.

Meanwhile, Alabama, currently ranked among the top contenders, faces pressure after narrowly defeating South Carolina last week. The Crimson Tide must navigate their upcoming games carefully to maintain their top playoff odds.

On another front, teams like Ole Miss and Georgia Tech, both 7-1, face steep tests to solidify their playoff chances. Ole Miss plays against a talented South Carolina squad, while Georgia Tech aims to defend its undefeated status against North Carolina State.

As November arrives, the stakes rise with the first CFP rankings set to be released next week. The upcoming weekend will be critical for teams looking to secure their playoff spots amidst tight competition.

With playoff implications on the line and numerous high-stakes games scheduled, fans should expect an exciting Saturday filled with potential upsets.