49ers’ Isaac Guerendo Records Career-High Rushing Yards in Loss to Cardinals

Rookie running back Isaac Guerendo made a noteworthy contribution in the San Francisco 49ers‘ narrow 24-23 defeat against the Arizona Cardinals on Sunday. Guerendo, serving as a backup to fellow running back Jordan Mason, rushed five times and achieved a career-high total of 22 yards. Additionally, he executed a kick return, covering 32 yards during the game held at Levi's Stadium.

The 24-year-old Guerendo, a product of the University of Louisville, stepped onto the field as Mason’s understudy. Mason, who carried the ball 14 times for 89 yards without scoring, has been a regular feature in the team’s lineup throughout the season. Despite the increased yardage in this game, Guerendo remains a secondary option for the 49ers’ offense, and his limited involvement in the team’s play suggests he may not be a strong candidate for fantasy football consideration ahead of their Thursday night matchup against the Seattle Seahawks.

San Francisco’s loss to Arizona marks an unexpected setback in the standings as the NFC West division race continues. The team will be looking to rebound and solidify their playoff aspirations in the upcoming fixture against a division rival.

The game saw Guerendo taking on a more prominent role than usual due to a tactical decision by the 49ers’ coaching staff. Nevertheless, his overall impact was constrained by limited opportunities within the game plan.