49ers vs. Rams: Preview, Injury Report, and Key Matchups for Week 15

The San Francisco 49ers and the Los Angeles Rams are set to clash in a crucial Week 15 matchup on Thursday, December 12, 2024, at Levi's Stadium in Santa Clara, California. The game, scheduled for 8:15 p.m. ET, will be broadcast on Amazon Prime Video.

The 49ers, currently standing at 6-7, are slight favorites with a spread of -2 points. The over/under for the game is set at 49 points. In their last five meetings, the 49ers have secured three wins against the Rams, scoring a total of 129 points to the Rams’ 94.

Both teams are dealing with significant injuries. The 49ers have 11 players on their injury report, including defensive end Nick Bosa and tackle Trent Williams, who have missed several games and are uncertain for Thursday’s game. Rookie running back Isaac Guerendo, who suffered a foot sprain against the Chicago Bears, is also a game-day decision.

The Rams, with a 7-6 record, have eight players on their injury report. Despite these challenges, the Rams have shown resilience, particularly with performances from key players like Kyren Williams, who has 1,013 rushing yards and 12 rushing touchdowns, and Matthew Stafford, who has 3,303 passing yards and 19 touchdowns this season.

The matchup is critical for both teams as they vie for a playoff spot. The 49ers are coming off a strong win against the Chicago Bears, while the Rams recently outlasted the Buffalo Bills in a high-scoring game. The game will be a test of each team’s ability to convert on third downs and capitalize in the red zone, areas where both teams have shown mixed results.

Defensively, the Rams have struggled, ranking 24th in points per game allowed and 27th in yards per game. However, they have been effective in forcing field goals when opponents reach the red zone. The 49ers’ defense, historically strong, has had a down year but showed improvement against the Bears.