49ers Running Backs Face New Challenges with Injuries and Roster Uncertainty

The San Francisco 49ers are once again grappling with significant injuries in their running back corps, a recurring issue that has plagued the team throughout the 2024 season. The latest setback involves rookie running back Isaac Guerendo, who is likely to miss the upcoming game against the Miami Dolphins due to a hamstring injury.

Guerendo’s injury is just the latest in a series of setbacks for the 49ers’ running backs. Earlier in the season, star running back Christian McCaffrey missed time due to injury, and Jordan Mason has been dealing with a high ankle sprain. This string of injuries has forced the 49ers to continually adjust their lineup and seek depth from other sources.

The 49ers have had to rely on a mix of veteran and rookie players to fill the gaps. Guerendo, a former track standout and converted wide receiver, had been seen as a promising addition to the team with his blend of size and speed. However, his hamstring injury now casts uncertainty over his immediate future with the team.

The team’s struggles with running back injuries highlight the challenges of maintaining a healthy roster in the physically demanding NFL. Despite these setbacks, the 49ers are looking to find functional replacements, possibly from practice squads, to mitigate the impact of these injuries.