Louisville vs. Clemson: College Football Week 10 Preview, Odds, and Predictions

The highly anticipated Week 10 college football matchup between the Louisville Cardinals and the No. 11 Clemson Tigers is set to take place on November 2, 2024. Clemson, after a Week 1 loss to Georgia, has rebounded strongly with six consecutive double-digit wins, putting them back in contention for another ACC Championship.

Louisville, on the other hand, has had a more inconsistent season. Despite taking care of some of the weaker teams in the ACC, the Cardinals are 0-3 against top-tier opponents, including losses to Notre Dame, SMU, and Miami. All three of these losses were one-possession games, indicating that Louisville is more competitive than their record suggests.

Clemson is currently favored by 10.5 points at home, with a total of 61 points predicted for the game. This spread and total suggest that oddsmakers expect a strong performance from Clemson’s offense, with a projected final score of around 36-25 in favor of the Tigers.

College Football Network‘s (CFN) First Power Matrix (FPM) aligns with these odds, giving Clemson a 79.6% chance of winning and Louisville a 20.4% chance. The FPM also indicates that Clemson is likely to win out the rest of their season, with high probabilities against their remaining opponents.

The key to the game lies in the performance of Louisville’s offensive line against Clemson’s formidable defensive front. If Louisville’s line can create running lanes and protect quarterback Tyler Shough, the Cardinals may have a chance to keep the game close. However, Clemson’s ability to establish physicality early and their deep talent pool make them favorites to pull ahead and secure the win.

Experts predict that Clemson will come out strong, as they have in previous games, and aim to avoid letting Louisville linger in the second half. Despite Louisville’s potential to make the game interesting, the consensus is that Clemson’s depth and talent will ultimately prevail.