Ohio State vs. Indiana Prediction: Odds, Picks, and Expert Analysis for Week 13 College Football Showdown

The highly anticipated Week 13 college football matchup between the No. 2 Ohio State Buckeyes and the No. 5 Indiana Hoosiers is set to take place at Ohio Stadium on Saturday, with kickoff scheduled for noon ET. The Buckeyes, favored by 10 points according to the latest odds via SportsLine consensus, are looking to extend their dominance in the series, which they lead 80-12-5.

Ohio State comes into the game on a strong note, having won four straight games, including a 31-7 blowout victory over Northwestern in their last outing. The Buckeyes boast one of the most talented rosters in the country, ranking first in the Big Ten in defensive scoring with 10.3 points allowed per game and second in offensive scoring with 37.8 points per game. Quarterback Will Howard has been impressive with 2,484 passing yards, 24 touchdowns, and six rushing touchdowns, while safety Caleb Downs is an All-American candidate and considered the top safety in college football.

Indiana, currently undefeated at 10-0 and 6-0 in the Big Ten, is coming off a bye week after their last win against Michigan on November 9. Despite their strong record, the Hoosiers face a significant challenge in Ohio Stadium, one of the toughest venues in college football. ESPN analyst Todd McShay predicts that Indiana will score early and frustrate Ohio State for the first two to three quarters but ultimately expects Ohio State’s defense to lock down and the Buckeyes’ run game to wear Indiana down late in the game.

SportsLine expert Jimmie Kaylor, who has a remarkable 208-132-6 record since Week 1 of the 2023 season, is leaning towards the Over on the point total of 52.5 points. Kaylor has also identified a critical X-factor that makes one side of the spread a must-back, though he is only sharing this information on SportsLine.

The betting lines for the game are as follows: Ohio State -10 on the spread, an over/under of 52.5 points, and money line odds of Ohio State -394 and Indiana +305.