Louisville vs. Boston College Prediction: Odds, Picks, and Key Matchup Analysis

The Louisville Cardinals and the Boston College Eagles are set to clash in a crucial Week 9 college football matchup on Friday, October 25, at Alumni Stadium in Chestnut Hill, Massachusetts. The Cardinals, with a record of 4-3 (2-2 in the ACC), are looking to bounce back from a high-scoring 52-45 loss to Miami, while the Eagles, also 4-3 (1-2 in the ACC), aim to snap a two-game losing streak after a 42-21 defeat to Virginia Tech on October 17.

Louisville is favored by 7.5 points, according to the latest odds, with the over/under set at 53.5 points. The Cardinals have been strong defensively, averaging 364.9 total yards allowed and 24.3 points per game, although their recent performance against Miami was an outlier. Quarterback Tyler Shough has been a key factor for Louisville, throwing for 2,016 yards, 18 touchdowns, and three interceptions, with wide receiver Ja'Corey Brooks as his top target.

Boston College, meanwhile, boasts a perfect 3-0 record at home this season. Under the guidance of head coach Bill O'Brien, the Eagles have become one of the most physical teams in the ACC. Dual-threat quarterback Thomas Castellanos is a significant threat, with 1,118 passing yards, 14 touchdown passes, four interceptions, 161 rushing yards, and one rushing score. The Eagles’ defense has been opportunistic, allowing just under 21 points and 351 yards per game, with nine interceptions in their last four contests.

Experts suggest that Boston College’s defense could slow down Louisville’s high-scoring offense, particularly given the Eagles’ extra two days of preparation and their strong home record. The home team has won each of the last seven meetings between these teams. While Louisville’s offense is potent, Boston College’s ability to create explosive plays and their defensive prowess make them a viable candidate to cover the spread.

For betting advice, SportsLine‘s Jimmie Kaylor, who has a strong track record in college football predictions, is leaning towards the Under on the point total and has identified a critical X-factor that makes one side of the spread a must-back. Another analyst recommends taking Boston College +7.5, citing the Eagles’ defensive strengths and their ability to limit Louisville’s scoring opportunities.