Purdue vs. Michigan State Prediction: Odds, Picks, and Betting Advice for Week 13 College Football

The Purdue Boilermakers and the Michigan State Spartans are set to clash in a Big Ten matchup on Friday, November 22, at Spartan Stadium in East Lansing, Michigan. Both teams are looking to snap their respective losing streaks, with Purdue having lost nine consecutive games and Michigan State aiming to end a three-game skid.

Michigan State, with a record of 4-6 overall and 2-5 in the Big Ten, is favored by 13.5 points in the latest odds. The Spartans need to win their remaining games against Purdue and Rutgers to become bowl eligible for the first time since 2021. Purdue, with a dismal 1-9 overall record and 0-7 in Big Ten games, is winless against FBS opponents this season.

The over/under for the game is set at 48.5 points, with Michigan State’s money line at -556 and Purdue’s at +406. SportsLine‘s expert, Jimmie Kaylor, who has a notable 208-132-6 record since Week 1 of the 2023 season, is leaning Over on the point total and has identified a critical X-factor that makes one side of the spread a must-back. Kaylor’s picks have been highly profitable, netting $6,694 for $100 bettors since the start of the 2023 season.

The SportsLine Projection Model, which simulates every FBS college football game 10,000 times, is also weighing in on the matchup. The model suggests that one side of the spread hits well over 60% of the time and is leaning Under on the total, projecting 44 combined points. The model has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks.

Key players to watch include Michigan State’s sophomore quarterback Aidan Chiles, who is a dual threat with 2,106 passing yards and 10 touchdowns, along with 210 rushing yards and three touchdowns. For Purdue, running back Devin Mockobee and tight end Max Klare have been bright spots, with Mockobee rushing for 652 yards and three touchdowns, and Klare catching 39 passes for 566 yards and three scores.