Study Links Higher Mortality to Kidney Transplant Failure in UK

Bristol, England – A recent study published in the Clinical Kidney Journal has revealed alarming statistics regarding kidney transplant failure. Patients who began dialysis after their kidney transplant experienced significantly higher estimated glomerular filtration rates (eGFR) at the start and faced nearly double the risk of 90-day mortality compared to those with native chronic kidney disease (CKD).

Led by Matthew Beresford from the Bristol Medical School, the study highlighted the disparities in treatment outcomes. “Our findings highlight disproportionately higher mortality; lower access to planned, home-based dialysis initiation; and initiation at higher eGFRs for those under specialist care with transplant failure compared to individuals with native CKD,” stated the authors.

The research was based on data from patients who started dialysis, excluding those who had pre-emptive transplantation, re-transplantation, or conservative management. This limitation may affect the comparability between the two patient groups. Additionally, the study’s sample was derived from a convenience sample of centers, which may restrict the generalizability of the results.

Researchers also noted that limited data hindered the ability to differentiate between patients who withdrew from dialysis without recovery and those who regained kidney function by the 90-day mark. One of the authors reported receiving support from Southmead Hospital Charity, while three others were employed by the UK Renal Registry.

This research sheds light on the critical challenges faced by kidney transplant patients and emphasizes the need for enhanced planning and resources to improve their care.