NFL Week 3 Preview: Key Matchups and Predictions

September 20, 2025 – This weekend marks the start of Week 3 in the NFL, which features several exciting matchups. The Rams will visit the Eagles, while the Chiefs are looking to find their rhythm against the Giants. Additionally, two undefeated teams, the Cardinals and 49ers, will clash in their pursuit of maintaining perfect records.

In a significant matchup, the Rams’ defense faces a unique challenge as they take on the Eagles’ potent offensive duo. Rams coach Sean McVay praised Eagles quarterback Jalen Hurts, who has proven he can impact games with both his arm and his legs.

“He can beat you with his arm, legs, or his mind,” McVay said. Despite the Rams’ excellent defensive start, they must now contend with an Eagles team that has surprised many this season.

Meanwhile, the Chiefs are looking to bounce back from an 0-2 start. Quarterback Patrick Mahomes aims to recapture his form against the Giants. The Chiefs’ offense has struggled, managing to average only 17 points per game thus far.

“We have to find ways to create more turnovers and give the ball back to [QB] Mahomes,” said Chiefs defensive tackle Chris Jones, emphasizing the importance of defense in their upcoming matchup.

At the same time, the Bengals, without their star quarterback Joe Burrow, are preparing to face the Vikings, whose offense has struggled early this season. Bengals quarterback Jake Browning, who took over after Burrow’s injury, has proven he can be effective, averaging 267 passing yards in the 2023 season while stepping in for Burrow.

“It needs to be better,” said Bengals offensive coordinator Dan Pitcher regarding the team’s running game. The absence of a strong run game could impact Browning’s performance.

In the NFC South, the Falcons are optimistic about their rookie defenders, who have made a positive impact in the first two weeks of the season. Their youth could play a crucial role in the Falcons’ matchup against the Panthers.

With kickoff approaching, analysts and fans are ready to see which teams will rise to the challenge and make a mark this weekend.